Grand theft auto VI
Grand Theft Auto VI looks set to contain the kind of content that has proved controversial in the past
Gamer Jess, known as "Rage Darling" online, usually streams multiplayer RPGs but said she's been "keeping an eye on" the upcoming game.
"If you're not at least intrigued by GTA, you're a bit of a black sheep at this point, because it's so big," she told BBC Newsbeat.
She said the series "has always been a man's game", but the new female perspective has left her intrigued.
While it's been a long time since GTA had a female protagonist in a mainline game - the last was back on the original PlayStation - she thinks the impact on the wider industry will be big.
"I think this is just going to show a lot of other game developers and AAA developers that having a female front and centre is a non-issue," she said